2,4-Diaminotoluene

Synonyms

Toluene-2,4-diamine; 1,3-Diamino-4-methylbenzene; 2,4-Diamino-1-methylbenzene; 2,4-Diamino-1-toluene; 2,4-Diaminotoluen [Czech]; 2,4-Diaminotoluene; 2,4-Diaminotoluol; 2,4-Tolamine; 2,4-Toluenediamine; 3-Amino-p-toluidine; 4-Methyl-1,3-benzenediamine; 4-Methyl-m-phenylenediamine; 4-m-Tolylenediamine; 5-Amino-o-toluidine; Benzofur MT; Brown for Fur T; C.I. Oxidation Base 35; CI Oxidation Base 35; Developer 14; Developer B; Developer DB; Developer DBJ; Developer MC; Developer MT; Developer MT-CF; Developer MTD; Developer T; Eucanine GB; Fouramine J; Fourrine 94; Fourrine M; Nako TMT; Pelagol Grey J; Pelagol J; Pontamine developer TN; Renal MD; TDA; Tertral G; Toluenediamine, o-; Tolylene-2,4-diamine; Zoba GKE; Zogen Developer H; m-Toluenediamine; m-Toluylendiamin [Czech]; m-Tolylenediamine; meta-Tolylenediamine; 1-Methyl-2,4-phenylenediamine; 1,3-Benzenediamine, 4-methyl-; 2,4-Toluene diamine; 2,4-Toluylenediamine; Benzenediamine, ar-methyl-; Toluenediamine; [ChemIDplus] ar-Methyl-m-phenylenediamine; Azogen Developer H; C.I. 76035; C.I. Oxidation Base; C.I. Oxidation Base 20; C.I. Oxidation Base 200; Developer H; Diaminotoluene; Fouramine; m-Diaminotoluene; m-Phenylenediamine, methyl-; m-Toluene diamine; m-Toluyenediamine; m-Tolyenediamine; Meta toluylene diamine; meta-Tolulenediamine; 4-Methyl-1,3-phenylenediamine; Methylphenylene diamine; MTD; Toluene-ar,ar-diamine; Toluylenediamine; Tolylenediamine; 2,4-Tolylenediamine; [CAMEO] 2,4-TDA; [ICSC] UN1709

Category

Amines, Aromatic

Description

Colorless solid; Darkened by air; [ICSC] Gray or brown powder or flakes; [Alfa Aesar MSDS]

Sources/Uses

Used as an intermediate for dyes, polymers, and other chemicals; Also used in hair dyes (banned by the EU in 2007); [HSDB] Allergic contact dermatitis in hairdressers; [Marks] Used mainly in the EU as an intermediate for toluylene diisocyanates (TDI); Very small quantities are also used to make dyes and other chemicals; [CPS&Q: RARs - Final Risk Assessment Report]

Comments

A skin, eye, and respiratory tract irritant; May cause skin sensitization, methemoglobinemia, and liver injury; Can be absorbed through skin; Possible carcinogen and mutagen; [ICSC] Commercially relevant products containing 2,4-toluylenediamine are 2,4/2,6-TDA (80/20) with 80% 2,4-TDA and 20% 2,6-TDA (CAS# 25376-45-8) and 2,4/2,6-TDA (65/35) with 65% 2,4-TDA and 35% 2,6-TDA (both produced as mixtures); 2,4-TDA of approximately 99% purity is also produced; [CPS&Q: RARs - Final Risk Assessment Report] Danger of skin sensitization; [MAK] May causes irritation and skin sensitization; Toxic by ingestion; Harmful by skin absorption; Prolonged or repeated ingestion exposure may cause damage to the kidneys, liver, blood, bladder, and reproductive system; Suspected mutagen and reproductive toxicant; Possible carcinogen; [Alfa Aesar MSDS]

Biomedical References

0.00017 mm Hg

Explanatory Notes

2,4-Toluenediamine vapor pressure at 106.5 deg C = 0.13 kPa (0.975 mm Hg); [ICSC] Flash point = 149 deg C; [NTP] VP from HSDB;

Reference Link #2

0.005 ppm

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Anticipated human carcinogen

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair