o-Toluidine

Synonyms

1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Amino-1-methylbenzene; 2-Aminotoluene; 2-Methyl-1-aminobenzene; 2-Methylaniline; 2-Methylbenzamine; 2-Methylbenzenamine; 2-Toluidine; Aniline, 2-methyl-; C.I. 37077; o-Aminotoluene; o-Methylaniline; o-Methylbenzenamine; o-Toluidin [Czech]; o-Toluidine; o-Toluidyna [Polish]; o-Tolylamine; [ChemIDplus] UN1708

Category

Amines, Aromatic

Description

Colorless to pale-yellow liquid with an aromatic, aniline-like odor; [NIOSH]

Sources/Uses

An intermediate used in the organic synthesis of dyes, pharmaceuticals, and other chemicals; [ACGIH]

Comments

Methemoglobinemia, bladder irritation, and hematuria have been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; [ICSC]

Reference Link #1

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

2 ppm

5 ppm

50 ppm

Excerpts from Documentation for IDLHs

Human data: It has been reported that a 60­minute exposure to 40 ppm produces severe toxic effects [Goldblatt 1955]. It has been reported that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences [Sax 1975].

0.26 mm Hg

0.02 ppm

Odor Threshold High

6.6 ppm

LC50 (rat) = 862 ppm/4h

Explanatory Notes

Odor threshold from AIHA; Flash point = 185 deg F; VP from HSDB;

high ambient temp required

MetHgb is secondary toxic effect

Yes

Established

Human carcinogen

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Bladder cancer

Activities

Activities with risk of exposure:

• Smoking cigarettes