1,2,3-Trichloropropane

Synonyms

1,2,3-Trichloropropane; Allyl trichloride; Glycerol trichlorohydrin; Glyceryl trichlorohydrin; Trichlorohydrin; Trichloropropane; [ChemIDplus] UN2810

Category

Chlorinated Aliphatics

Description

Colorless liquid with a chloroform-like odor; [NIOSH]

Sources/Uses

Used as a curing agent for polysulfides and a chemical intermediate; Used in the past as a solvent and extractive agent; [ACGIH] Used as a degreaser, paint remover, and solvent for resins, waxes, and oils; [HSDB]

Comments

Mice have hepatic damage and die after exposure to 5000 ppm for 20 minutes. Rats and guinea pigs have CNS depression after exposures to 800, 2100, or 5000 ppm for 30 minutes. Workers complained of unpleasant odor and irritation of the eyes and throat at 100 ppm. TLV Basis is cancer. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury; Inhalation of high concentrations can cause CNS depression; [ICSC]

Biomedical References

0.005 ppm

50 ppm

100 ppm

Excerpts from Documentation for IDLHs

It has been reported that objectionable ocular and mucosal irritation were experienced after 15 minutes of exposure to 100 ppm [Silverman et al. 1946].

3.69 mm Hg

100 ppm

LCLo (rat) = 500 ppm/4H

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 180 deg F; VP from HSDB;

Animal studies (whole body): 1 day; [TDR, p. 1194]

Reference Link #2

high ambient temp required

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Probable (2a)

Anticipated human carcinogen

Suspected Human

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Degreasing
• Painting (Solvents)
• Plastic Composites Manufacturing