Cycloheximide
Agent Name
Cycloheximide
CAS Number
66-81-9
Formula
C15-H23-N-O4
Major Category
Pesticides
Synonyms
(1S-(1alpha(S*),3alpha,5beta))-4-(2-(3,5-Dimethyl-2-oxo-cyclohexyl))-2-hydroxyethyl-2,6-piperidinedione; 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; 3-(®-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; 3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; 3-(2R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethylglutarimide; 4-((2R)-2-((1S,3S,5S)-(3,5-Dimethyl-2-oxocyclohexyl))-2-hydroxyethyl)piperidine-2,6-dione; Acti-Aid; Acti-Dione; Actidion; Actidione BR; Actidione PM; Actidione TGF; Actidone; Actispray; Aktidion [Czech]; CBC 500046; CX; Cicloheximida [INN-Spanish]; Cicloheximide; Cicloheximidum [INN-Latin]; Glutarimide, 3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-; Hizarocin; Kaken; Naramycin; Naramycin A; Neocycloheximide; TZA; U 4527; U-4527; beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; [ChemIDplus] UN2588
Category
Plant Growth Regulators
Description
Colorless solid; [ICSC] White to beige powder; [MSDSonline]
Sources/Uses
Antibiotic compound isolated from Streptomyces griseus; [Merck Index] Used as a fungicide, plant growth regulator, protein synthesis inhibitor, and to stimulate the natural abscission process (pre-harvest use on citrus); [HSDB]
Comments
A skin and eye irritant; May be very toxic by ingestion; [ICSC] A skin irritant; At lethal doses, causes bloody diarrhea, tremors, excitement, coma, and cardiovascular collapse; LD50 = 500 mg/kg in monkeys and dogs, but only 2 mg/kg in rats; [HSDB] Extremely toxic (probable oral lethal dose in humans is 5-50 mg/kg, or 7 drops to 1 teaspoonful for a 150-lb. person); [CAMEO] An irritant; May cause skin sensitization; May cause damage to liver and spleen, and have effects on the blood; [MSDSonline] Toxic to embryo of mice at a maternal dose of 30 mg/kg; Inhibits maturation of amphibian spermatocytes; [REPROTOX]
Biomedical References
Exposure Assessment
Vapor Pressure
4.45E-13 mm Hg
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Reproductive Toxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: