Cyclophosphamide
Agent Name
Cyclophosphamide
CAS Number
50-18-0; 6055-19-2
Formula
C7-H15-Cl2-N2-O2-P
Major Category
Other Classes
Synonyms
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin; 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; ASTA B518; B 518; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester; CB 4564; Ciclofosfamida [INN-Spanish]; Ciclophosphamide [INN]; Clafen; Claphene; Cyclophosphamid; Cyclophosphamidum [INN-Latin]; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclophosphoramide; Cyclostin; Cyklofosfamid [Czech]; Cytophosphan; Cytophosphane; Cytoxan; Endoxan; Endoxan R; Endoxan-asta; Endoxana; Endoxanal; Genoxal; Lyophilized cytoxan; N,N-Bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide; N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid [German]; N,N-Di(2-chloroethyl)-N,O-propylene-phosphoric acid ester diamide; Neosar; Occupation, cyclophosphamide exposure; Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. Ester; Procytox; SK 20501; Sendoxan; Zyklophosphamid [German]; [ChemIDplus]
Category
Other Organic Compounds
Description
White odorless solid; Liquefies upon loss of crystallization water; Darkens on light exposure; [ICSC] White odorless crystalline solid; [MSDSonline]
Sources/Uses
Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug; [Merck Index] An alkylating agent; [HSDB]
Comments
A skin, eye, and respiratory tract irritant; May cause effects on the blood, bladder, CNS, lungs, and heart; Carcinogenic to humans and may cause reproductive toxicity and heritable genetic damage; [ICSC] A severe skin irritant; Common side effects at therapeutic doses include alopecia, sterility, gastrointestinal disturbances, thrombocytopenia, anemia, leukopenia, and life-threatening hemorrhagic cystitis; Rare side effects include hepatitis, interstitial pneumonitis, and pulmonary fibrosis; Teratogenic; [HSDB] May cause serious eye injury; Can be absorbed through skin; [MSDSonline]
Biomedical References
Exposure Assessment
Vapor Pressure
4.45E-05 mm Hg
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Reproductive Toxin
Yes
IARC Carcinogen
Established
NTP Carcinogen
Human carcinogen
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.