Phosfolan

Synonyms

Cyolane; (Diethoxyphosphinyl)dithioimidocarbonic acid cyclic ethylene ester; 1,2-Ethanedithiol, cyclic S,S-ester with phosphonodithioimidocarbonic acid P,P-diethyl ester; 1,2-Ethanedithiol, cyclic ester with P,P-diethyl phosphonodithioimidocarbonate; 2-(Diethoxyphosphinylimino)-1,3-dithiolane; AC 47031; American Cyanamid 47031; American Cyanamid AC 47,031; American Cyanamid CL-47031; American Cyanamide 47031; CL 47031; Cyclic ethylene P,P-diethyl phosphonodithioimidocarbonate; Cyclic ethylene(diethoxyphosphinothioyl)dithioimidocarbonate; Cyolane insecticide; Diethyl 1,3-dithiolan-2-ylidenephosphoramidate (9CI); EI 47031; ENT 25,830; Imidocarbonic acid, (diethoxyphosphinyl)dithio-, cyclic ethylene ester; Imidocarbonic acid, phosphonodithio-, P,P-diethyl cyclic ethylene ester; Imidocarbonic acid, phosphonodithio-, cyclic ethylene P,P-diethyl ester; OMS 646; P,P-Diethyl cyclic ethylene ester of phosphonodithioimidocarbonic acid; P,P-Diethyl cyclic ethylene phosphonodithioimidocarbonate (8CI); Phospholan [ISO-French]; Phosphoramidic acid, 1,3-dithiolan-2-ylidene-, diethyl ester; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless to yellow solid; [CAMEO] Yellow crystalline solid; [MSDSonline]

Sources/Uses

Used as systemic insecticide; [HSDB]

Comments

Decreased erythrocyte cholinesterase activity in heavy occupational exposure by 31-43% by the end of the first hour; Nearly half of the cholinesterase activity had recovered by 48 hours, with full recovery taking 3-4 weeks; No adverse clinical observations in 90 day feeding with dogs at 1 mg/kg; Cholinesterase inhibition noted in animal studies, but no chronic neurotoxicity seen in chickens surviving high doses; [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

5.3E-05 mm Hg

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)