Naled

Synonyms

1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate; Alvora; Arthodibrom; BRP; Bromchlophos; Bromex; Bromex (insecticide); Bromex 50; Dibrom; Dibromfos; Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate; Ethanol, 1,2-dibromo-2,2-dichloro-, dimethyl phosphate; Flibol Ex; Fosbrom; Fosforan O-1,2-dwubromo-2,2-dwuchloroetylo-O,O-dwumetylowy [Polish]; Hibrom; Naledu [Polish]; Nikabrom; O,O-Dimethyl O-2,2-dichloro-1,2-dibromoethyl phosphate; O,O-Dimethyl-O-(1,2-dibrom-2,2-dichlor-aethyl)-phosphat [German]; O,O-Dimethyl-O-(1,2-dibromo-2,2-dichloroethyl)phosphate; O-(1,2-Dibrom-2,2-dichlor-aethyl)-O,O-dimethyl-phosphat [German]; O-(1,2-Dibromo-2,2-dicloro-etil)-O,O-dimetil-fosfato [Italian]; O-(1,2-Dibroom-2,2-dichloor-ethyl)-O,O-dimethyl-fosfaat [Dutch]; OMS 75; Ortho 4355; Ortho-dibrom; Orthodibromo; Phosphate de O,O-dimethyle et de O-(1,2-dibromo-2,2-dichlorethyle) [French]; Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester (8CI)(9CI); RE-4355; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless to white solid or straw-colored liquid (above 80 degrees F) with a slightly pungent odor. [insecticide]; [NIOSH]

Sources/Uses

Used to kill aphids, mites, mosquitoes, and flies; also used by veterinarians to treat worm infections in dogs; [EXTOXNET] Used as an insecticide and acaricide in field crops, greenhouses and mushroom cultivation; Also used to kill mosquitoes; [ACGIH]

Comments

Classified as "moderately toxic," naled has an LD50 of 91 to 430 mg/kg in rats; Skin sensitization has been reported; [EXTOXNET] Structurally similar to dichlorvos; A dermal sensitizer; [ACGIH] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Yes

0.1 mg/m3, inhalable fraction and vapor

3 mg/m3

0.5 mg/m3, inhalable fraction

200 mg/m3

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Because no useful data on acute inhalation toxicity are available, the chosen IDLH has been estimated from the male rat oral LD50 of 250 mg/kg [Gaines 1969 cited by ACGIH 1971]. ACGIH [1971] also reported that the acute toxicity data, inhalation data, and experience to date indicate that this is not a highly dangerous material. . . . Human data: None relevant for use in determining the revised IDLH.

0.0002 mm Hg

LC (mice) > 1,500 mg/m3/6h

Reference Link #2

Yes

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)