Deoxynivalenol
Agent Name
Deoxynivalenol
Alternative Name
Vomitoxin
CAS Number
51481-10-8
Formula
C15-H20-O6
Major Category
Biological Agents
Synonyms
Vomitoxin; 12,13-Epoxy-3-alpha,7-alpha,15-trihydroxy-9-trichothecen-8-one; 4-Deoxynivalenol; 4-Desoxynivalenol; DON; Dehydronivalenol; Desoxynivalenol; Rd toxin; [ChemIDplus]
Category
Mycotoxins
Description
Solid; [Merck Index]
Sources/Uses
A trichothecene mycotoxin; [Merck Index] Reportedly used as biological/chemical warfare agent; [HSDB] Zearalenone, deoxynivalenol, and fusarenon X are mycotoxins produced by 3 Fusarium species (F. graminearum, F. culmorum, and F. crookwellense) that grow on wheat, barley, and maize in humid conditions. [IARC] Common contaminant of barley, corn, rye, safflower seeds, wheat, and mixed feeds; [Reference #1]
Comments
In humans, severe gastrointestinal reactions occur after ingestion. In pigs, causes feed refusal and vomiting; Causes immunosuppression in mice studies; No data on carcinogenicity in animals; [IARC] Trichothecene mycotoxins causes bone marrow suppression, leukopenia, immunosuppression, and secondary sepsis; [HSDB] Inhibits eukaryotic protein synthesis; Less potent than T-2 toxin; Has also been called "vomitoxin" and "food-refusal factor." [Reference #1] Fatal if swallowed; Causes mild skin irritation; [Aldrich MSDS] See "T-2 toxin."
Reference Link #1
Biomedical References
Exposure Assessment
Vapor Pressure
6.8E-11 mm Hg
Adverse Effects
IARC Carcinogen
Not classifiable
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.