Diphenylamine

Synonyms

Aniline, N-phenyl-; Anilinobenzene; Benzenamine, N-phenyl-; Benzene, (phenylamino)-; Benzene, anilino-; Big Dipper; C.I. 10355; CI 10355; DFA; DPA (VAN); Deccoscald 282; Difenylamin [Czech]; Diphenylamine; N,N-Diphenylamine; N-Fenylanilin [Czech]; N-Phenylaniline; N-Phenylbenzenamine; Naugalube 428L; No-Scald; No-Scald DPA 283; Phenylaniline; Scaldip; Shield DPA; [ChemIDplus] UN3077

Category

Amines, Polyaromatic

Description

Colorless, tan, amber, or brown crystalline solid with a pleasant, floral odor. (fungicide); [NIOSH]

Sources/Uses

Used as an antioxidant, stabilizer of explosives, fungicide, and analytical chemical reagent; also used in the manufacture of dyes and pesticides; [ACGIH] Used to make dyes, to stabilize nitrocellulose explosives and celluloid, to treat screwworm topically (veterinary), and to test for nitrate or nitrite poisoning; [Merck Index]

Comments

The toxicity of diphenylamine is similar to that of aniline. Hepatotoxic effects have been demonstrated in animals. It can cause bladder irritation and induce methemoglobinemia in workers. As a skin sensitizer it cross-reacts with p-phenylene diamine. [ACGIH] May have effects on the kidneys and blood; A skin, eye, and respiratory tract irritant; [ICSC]

Reference Link #1

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Insufficient data

10 mg/m3

5 mg/m3, inhalable fraction

0.00067 mm Hg

0.02 ppm

Explanatory Notes

Odor threshold from AIHA; Flash point = 307 deg F; VP from HSDB;

Reference Link #2

must be preheated

Yes

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Possible (2b)

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Methemoglobinemia, acute