Ethyl amyl ketone

Synonyms

5-Methyl-3-heptanone; 2-Methylbutyl ethyl ketone; 3-Methyl-5-heptanone; 5-Methyl-3-heptanone; Ethyl 2-methylbutyl ketone; Ethyl sec-amyl ketone; 3-eptanone, 5-methyl-; [ChemIDplus] EAK; [ACGIH]

Category

Ketones (<C12)

Description

Colorless liquid with a pungent odor; [NIOSH]

Sources/Uses

Used as a solvent for resins; [ACGIH]

Comments

Narcosis induced in animal inhalation studies. Animals fed 820 mg/kg/day develop evidence of peripheral neuropathy. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Biomedical References

Insufficient data

10 ppm

25 ppm

10 ppm

100 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that 0 of 6 rats died, but 3 of 6 mice died when exposed for 4 hours to about 3,000 ppm [Shell 1958]. . . . Human data: Humans exposed to 25 ppm experienced irritation of the eyes and respiratory tract and detected a strong odor, while 100 ppm caused irritation of the mucous membranes, headache, and nausea which was too severe to tolerate for more than a few minutes [Clayton and Clayton 1981].

5.03 mm Hg

5.9 ppm

760 ppm

LCLo (rat) =3,484 ppm/8H

Explanatory Notes

Odor threshold from AIHA;

Acute solvent syndrome

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Plastic Composites Manufacturing