Difenacoum

Synonyms

2H-1-Benzopyran-2-one, 3-(3-(1,1'-biphenyl)-4-yl-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-; 3-(3-(1,1'-Biphenyl)-4-yl-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-2H-1-benzopyran-2-one; 3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin; Difenakum [Czech]; Diphenacoum; Neosorexa; Neosorexa PP580; Ratak; WBA 8107; [ChemIDplus] UN3027

Category

Rodenticides, Anticoagulant

Description

Off-white odorless solid; [HSDB]

Sources/Uses

Used as second generation anticoagulant rodenticide; [Merck Index] Registered in 2007 for use in the US in and around buildings and in transport vehicles; Has been registered in European countries since the 1970's; [Reference #1]

Comments

A vitamin K antagonist--causes clotting factor disruption and bleeding tendency; Two patients had abnormal vitamin K1 metabolism for more than 18 months after exposure, although prothrombin time and vitamin K-dependent clotting factors were normal; No unscheduled DNA synthesis induced in rat hepatocytes; [HSDB] See "Warfarin."

Reference Link #1

Biomedical References

1.2E-06 mm Hg

LC50 (rat) => 3.64 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Coumarin derivative pesticide, solid, toxic."

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)