1,2-Benzenediamine dihydrochloride

Synonyms

o-Phenylenediamine dihydrochloride; 1,2-Phenylenediamine dihydrochloride; [ChemIDplus] UN1673

Category

Amines, Aromatic

Description

Brownish-yellow solid; [CAMEO]

Sources/Uses

Used to make dyes; [CAMEO] Not commercially produced in the US; [HSDB]

Comments

Has the potential to form methemoglobin; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS]; Harmful by ingestion, inhalation, or skin absorption; May cause allergic skin reaction; Suspected cause of cancer and genetic defects; [Aldrich MSDS] See "p-Phenylenediamine."

Biomedical References

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylenediamines."

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic