1,3-Benzenediamine dihydrochloride

Synonyms

1,3-Benzenediamine hydrochloride; 1,3-Diaminobenzene dihydrochloride; 1,3-Phenylenediamine dihydrochloride; 3-Aminoaniline dihydrochloride; m-Aminoaniline dihydrochloride; m-Benzenediamine dihydrochloride; m-Diaminobenzene dihydrochloride; m-Phenylenediamine hydrochloride; m-Phenylenediamine, dihydrochloride; meta-Aminoaniline dihydrochloride; meta-Benzenediamine dihydrochloride; meta-Diaminobenzene dihydrochloride; [ChemIDplus] UN1673

Category

Amines, Aromatic

Description

Off-white powder; [MSDSonline]

Sources/Uses

Used in hair dyes and as an analytical reagent for nitrite; No known commercial production in the US currently or in the past; [HSDB]

Comments

Has the potential to form methemoglobin; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS] An irritant; Can be absorbed through skin; May cause skin sensitization; [MSDSonline] See "p-Phenylenediamine."

Biomedical References

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylenediamines."

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair