2-Methyl-1,4-benzenediamine dihydrochloride

Synonyms

1,4-Benzenediamine, 2-methyl-, dihydrochloride; 2,5-Diaminotoluene dihydrochloride; Toluene-2,5-diamine, dihydrochloride; p-Toluenediamine dihydrochloride; [ChemIDplus]

Category

Amines, Aromatic

Description

Solid; [MSDSonline]

Sources/Uses

Used in hair dyes; [HSDB]

Comments

Teratogenic in mice dosed by SC or IP injection on day eight of pregnancy; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An irritant; May cause skin sensitization; [MSDSonline] See "2,5-Diaminotoluene." See "p-Phenylenediamine."

Biomedical References

4.12E-12 mm Hg

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair