Dioscorine
Agent Name
Dioscorine
CAS Number
3329-91-7
Formula
C13-H19-N-O2
Major Category
Biological Agents
Synonyms
Spiro(2-azabicyclo(2.2.2)octane-5,2'-(2H)pyran)-6'(3'H)-
one, 2,4'-dimethyl-, (1R-(1alpha,4alpha,5alpha))-; [ChemIDplus]
Category
Plant Toxins
Description
Greenish-yellow solid; [MSDSonline]
Sources/Uses
Naturally occurring alkaloid in toxic yams of the genus dioscorea; [HSDB]
Comments
Has a picrotoxin-like action; Emergency treatment: Symptomatic plant ingestion; [HSDB] Picrotoxin is a GABA antagonist that causes seizures. [Ford, p. 156] Intraperitoneal LD50 (mouse) = 60 mg/kg; Causes seizures at lethal doses; [RTECS]
Biomedical References
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.