Dipropylene glycol

Synonyms

Dipropylene glycol (6CI); Dipropylenglykol; Oxybispropanol; Propanol, oxybis-; DPG; [ChemIDplus]

Category

Propylene Glycols

Description

Colorless, odorless liquid; [HSDB] Hygroscopic; [CHEMINFO]

Sources/Uses

Used in antifreeze, air sanitizers, cosmetic stabilizers, polyester and alkyd resins, reinforced plastics, plasticizers, solvents, and steam set printing inks; [HSDB] Used in hydraulic break fluids, cutting oils, textile lubricants, industrial soaps, pesticide solvents, fragrances, skin care products, deodorants, hair care products, shaving products, facial makeup, and bath and shower products; [CHEMINFO]

Comments

Readily absorbed by GI tract and metabolically converted into propylene glycol; No deaths in animals inhaling 6-8 g/m3; 30% of rats exposed to 10% DPG in drinking water have kidney lesions; No fetal toxicity or teratogenicity in rats; [OECD SIDS: Dipropylene glycol (mixed isomers and dominant isomer) - 2001] May cause minor eye irritation; [CAMEO] Commercial dipropylene glycol (CAS # 25265-71-8) is composed of 3 isomers: (2,2' -dihydroxydiisopropropylether (CAS # 108-61-2); 2,2' -dihydroxydipropylether (CAS # 110-98-5); 2-hydroxypropyl-2'-hydroxyisopropylether (CAS # 106-62-7); [eChemPortal: SIDSUNEP] Causes mainly kidney and also liver and testicular injury in high-dose feeding studies of experimental animals; Oral LD50 (rat) = 14.8 ml/kg; [HSDB] May cause irritation; [MSDSonline] See "Propylene glycol."

Biomedical References

100 mg/m3, inhalable fraction

0.0319 mm Hg

Explanatory Notes

Flash point = 120 deg C; [HSDB] VP from ChemIDplus;

must be preheated

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Yes

Processes

Industrial Processes with risk of exposure:

• Dressing Hair
• Metal Machining
• Painting (Pigments, Binders, and Biocides)