Glycidol

Synonyms

1,2-Epoxy-3-hydroxypropane; 1-Hydroxy-2,3-epoxypropane; 1-Propanol, 2,3-epoxy-; 2,3-Epoxy-1-propanol; 2,3-Epoxypropanol; 2-(Hydroxymethyl)oxirane; 2-Hydroxymethyloxiran; 3-Hydroxy-1,2-epoxypropane; 3-Hydroxypropylene oxide; Allyl alcohol oxide; Epihydrin alcohol; Epoxypropyl alcohol; Glycide; Glycidol; Glycidyl alcohol; Hydroxymethyl ethylene oxide; Methanol, oxiranyl-; Monoepoxide glycidol; Oxiranemethanol; Oxiranylmethanol; [ChemIDplus] UN2810

Category

Epoxides

Description

Colorless, slightly viscous liquid; [HSDB]

Sources/Uses

Used primarily as a stabilizer of vinyl polymers; [ACGIH]

Comments

Mice and rats exposed to high concentrations develop pneumonitis and emphysema; Rabbits show skin irritation and reversible corneal burns after skin and eye exposure; [ACGIH] In lethal inhalation studies of rodents, pulmonary edema was usually the cause of death; There is no experimental data, but glycidol, an epoxide, should be considered a potential skin and respiratory sensitizer; [HSDB]

Biomedical References

Insufficient data

2 ppm

50 ppm

150 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956]. \ Human data: None relevant for use in determining the revised IDLH.

5.59 mm Hg

LC50 (rat) = 580 ppm/8H

Explanatory Notes

Flash point = 162 deg F; VP =5.59 mm Hg @ 25 deg C; [HSDB]

Reference Link #2

Yes

Skin burns

Probable (2a)

Anticipated human carcinogen

Confirmed Animal

Processes

Industrial Processes with risk of exposure:

• Plastic Composites Manufacturing