Cadusafos

Synonyms

Ebufos; FMC 67825; O-Ethyl S,S-bis(1-methylpropyl) phosphorodithioate (9CI); O-Ethyl-S,S-bis(1-methylpropyl)phosphorodithioate; O-Ethyl-S,S-di-sec-butylphosphorodithioate; Rugby; S,S-Di-sec-butyl O-ethyl phosphorodithioate; Sebufos; Sebuphos; Taredan; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Colorless to yellow liquid; [Merck Index] Pale yellow liquid; [MSDSonline]

Sources/Uses

Used for broad control of parasitic plant nematodes and soil insects in fruits, vegetables, and other crops; [HSDB] Used as nematicide and soil insecticide on bananas in Central and South America; [Reference #1]

Comments

No significant adverse effects were observed besides inhibition of cholinesterase activity in high-dose animal studies; In a two generation feeding study with rats the LOEL for reproductive toxicity was 0.5 ppm (0.025 mg/kg/day) based on marked decrease in live birth index; No evidence of teratogenicity based on studies with rabbits and rats; [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Not currently registered as a pesticide for use in the US; [HSDB] No US registrations; [Reference #1]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Yes

0.001 mg/m3, inhalable fraction and vapor

0.0009 mm Hg

LC50 (rat) = 32 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Reference Link #2

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)