Hexafluoroacetone
Agent Name
Hexafluoroacetone
CAS Number
684-16-2
Formula
C3-F6-O
Major Category
Toxic Gases & Vapors
Synonyms
1,1,1,3,3,3-Hexafluoro-2-propanone; 2-Propanone, 1,1,1,3,3,3-hexafluoro-; 6FK; Acetone, hexafluoro-; GC 7887; Hexafluoroacetone; Perfluoro-2-propanone; Perfluoroacetone; [ChemIDplus] UN2420
Category
Corrosive Gases
Description
Colorless gas with a musty odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]
Sources/Uses
Used in the synthesis of organic chemicals and polymers; [ACGIH]
Comments
In 4-hour inhalation studies of rats, 300 ppm is lethal, 200 ppm causes liver and kidney injury, and 100 ppm causes testicular damage; evidence of bone marrow injury is also seen; [ACGIH] Possible frostbite from contact with liquid; [NIOSH] Inhalation of vapor can cause pulmonary edema; A skin, eye, and respiratory tract irritant; [ICSC]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
TIH
Yes
TLV (ACGIH)
0.1 ppm
IDLH (NIOSH)
9 ppm
Lethal Concentration
LC50 (rat) = 275 ppm/3h
ERPG-1
Not appropriate
ERPG-2
1 ppm
ERPG-3
50 ppm
Adverse Effects
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Nephrotoxin
Yes
Reproductive Toxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: