Ethyl acetoacetate

Synonyms

1-Ethoxybutane-1,3-dione; 3-Oxobutanoic acid ethyl ester; Acetoacetic acid, ethyl ester; Acetoctan ethylnaty [Czech]; Active acetyl acetate; Active acetylacetate; Butanoic acid, 3-oxo-, ethyl ester; EAA; Ethyl 3-oxobutanoate; Ethyl 3-oxobutyrate; Ethyl acetyl acetate; Ethyl acetylacetate; Ethyl acetylacetonate; Ethyl beta-ketobutyrate; Ethylacetacetat [Czech]; Ethylester kyseliny acetoctove [Czech]; [ChemIDplus]

Category

Esters, Other

Description

Colorless liquid with a fruity odor; [Hawley]

Sources/Uses

Used in lacquers and plastics, to make pharmaceuticals, and as a flavoring agent; [Hawley] Used to make inks, photographic and vat dyes, yellow pigments in paints, amino acids, methionine, analgesics, and aminopyrene; [HSDB] Primarily used as a chemical intermediate; Also used in consumer cleaning supplies and cosmetics and as a solvent in paints; [ExPub: European Commission]

Comments

A skin and eye irritant; [Hawley] A mutagen; Severe irritant in rabbit eye; [RTECS] A skin, eye, and respiratory tract irritant; [ICSC] "Following repeated oral exposure of ethyl acetoacetate in rats, no treatment-related adverse effects (including haematology, clinical chemistry, gross necropsy and histopathology) were reported up to 1000 mg/kg bw/d. There is no information on health effects in humans following repeated exposure to ethyl acetoacetate via any route." [ChemPortal: SIDS] Safe when used as a flavoring agent in food; [JECFA] An eye irritant; A moderate skin and mucous membrane irritant; Emergency treatment: "irritants"; [HSDB] An irritant; May cause serious eye injury; [MSDSonline]

Biomedical References

0.78 mm Hg

LC50 (rat) > 1,380 ppm/4h

Explanatory Notes

VP from ChemIDplus;

high ambient temp required

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)