Flocoumafen

Synonyms

4-Hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin; Flocoumafene [ISO-French]; Storm; Stratgem; WL 108366; [ChemIDplus] UN3027

Category

Rodenticides, Anticoagulant

Description

White solid; [Merck Index] Off-white solid; [HSDB] Off-white powder; [MSDSonline]

Sources/Uses

Used as anticoagulant rodenticide for urban, industrial, and agricultural applications (effective for rodents resistant to other anticoagulants); [HSDB]

Comments

A vitamin K antagonist--causes clotting factor disruption and bleeding tendency; More embryotoxic than teratogenic in studies with rats and chickens; Non-lethal oral doses caused decrease in ovarian weight and transient infertility in female rats; [HSDB] Can be absorbed through skin; May cause problems with blood clotting, with symptoms appearing days after exposure; [ICSC] Second generation anticoagulant rodenticide; Rapidly absorbed by blood following single oral dose (maximum plasma concentration in four hours); Highest tissue accumulation in the liver (mostly unchanged parent compound); No pathological changes observed in rats fed non-lethal doses; Not irritating to skin or eyes of rabbits; Not sensitizing to guinea pig skin; No evidence of mutagenicity in any studies (i.e. reverse gene mutation, chromosomal aberrations); [INCHEM] See "Warfarin."

Biomedical References

1E-12 mm Hg

LC50 (rat) = 160-1,400 mg/m3/4h (see notes below)

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Coumarin derivative pesticide, solid, toxic." LC50 obtained using 0.5% manufacturing master mix as dust;

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)