Fluoroacetamide

Synonyms

1081; 2-Fluoroacetamide; AFL 1081; Amid kyseliny fluoroctove [Czech]; Baran; Compound 1081; FAA; Fluorakil 100; Fluorkill; Fluoroacetic acid amide; Fluoroakil 100; Flutritex 1; Fussol; Megatox; Monofluoroacetamide; Navron; Yanock; Acetamide, 2-fluoro-; [ChemIDplus] UN2811

Category

Rodenticides

Description

Colorless or white solid; [HSDB] Fine faintly brown crystals; [MSDSonline]

Sources/Uses

Used as rodenticide and insecticide; [HSDB] Used as a rodenticide in the US and as pesticide in other countries; The only continued registration in the US after 1980 was for rat control in sewers with application by certified professionals and highly restricted; [EPA OHM/TADS]

Comments

Can be absorbed through skin; In animal experiments, toxic to the heart (fatal arrhythmias) and reproductive system; [ICSC] A testicular poison in animal studies; [HSDB] Probable oral lethal dose in humans is less than 5 mg/kg (less than 7 drops); Inhibits oxygen metabolism by cells; [CAMEO] Converted to fluoroacetic acid in vivo causing buildup of fluorocitric acid and inhibiting Krebs cycle; [UNEP] May cause irritation; Can be absorbed through skin; Metabolized to fluoroacetate (highly toxic); [MSDSonline] See "Sodium fluoroacetate."

No longer registered with the EPA for use in the US; [HSDB] Banned in the EU for use as pesticide; [eChemPortal: ESIS] Use in Israel and Japan (insecticide for citrus) requires special permit from the government (as of 1991); [UNEP]

Biomedical References

0.991 mm Hg

LC50 (mice) = 550 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s." VP from ChemIDplus;

Other CNS neurotoxin

Yes

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)