N-Isopropylaniline

Synonyms

N-IPA; Isopropylaniline; N-(1-Methylethyl)benzenamine; N-Phenylisopropylamine; [NIOSH]

Category

Amines, Aromatic

Description

Clear, yellowish liquid with a sweet, aromatic odor; [NIOSH]

Sources/Uses

Used in synthesis of dyes for acrylic fibers and other chemicals; [ACGIH]

Comments

Like aniline and N,N-dimethylaniline, N-isopropylaniline can cause methemoglobinemia after skin and inhalation exposure in the workplace. [ACGIH] Can induce methemoglobinemia; May cause skin sensitization; [ICSC]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

2 ppm

0.03 mm Hg

LC50 (rat) = 1,100 mg/m3/4h

Explanatory Notes

Flash point = 87 deg C; VP = 4 Pa at 25 deg C; [ICSC]

Reference Link #2

Yes

MetHgb is primary toxic effect

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Methemoglobinemia, acute