Formothion

Synonyms

2-Dimethoxyphosphinothioylthio-N-formyl-N-methylacetamide; Acetamide, N-formyl-2-mercapto-N-methyl-, S-ester with O,O-dimethyl phosphorodithioate; Aflix; Afliz; Afliz [Sandoz]; Anthio; Anthio 25; Antio; CP 53926; ENT 27,257; Formothion 25 EC; J-38; N-Formyl-N-methylcarbamoylmethyl O,O-dimethyl phosphorodithioate; O,O-Dimethyl S-(N-formyl-N-methylcarbamoylmethyl) phosphorodithioate; O,O-Dimethyl S-(N-methyl-N-formylcarbamoylmethyl)phosphorodithioate; O,O-Dimethyl dithiophosphorylacetic acid N-methyl-N-formylamide; O,O-Dimethyl phosphorodithioate N-formyl-2-mercapto-N-methylacetamide S-ester; O,O-Dimethyl phosphorodithioate S-ester with N-formyl-2-mercapto-N-methylacetamide; O,O-Dimethyl-S-(3-methyl-2,4-dioxo-3-aza-butyl)-dithiofosfaat [Dutch]; O,O-Dimethyl-S-(3-methyl-2,4-dioxo-3-aza-butyl)-dithiophosphat [German]; O,O-Dimethyl-S-(N-methyl-N-formyl-carbamoylmethyl)-dithiophosphat [German]; O,O-Dimetil-S-(N-formil-N-metil-carbamoil-metil)-ditiofosfato [Italian]; OMS-968; P 1; Phosphorodithioic acid, O,O-dimethyl ester, N-formyl-2-mercapto-N-methylacetamide S-ester; Phosphorodithioic acid, S-(2-(formylmethylamino)-2-oxoethyl) O,O-dimethyl ester; S 6900; S-(2-(Formylmethylamino)-2-oxoethyl) O,O-dimethyl phosphorodithioate; S-(2-(Formylmethylamino)-2-oxoethyl) O,O-dimethylphosphorodithioate; S-(Formyl(methyl)carbamoylmethyl) O,O-dimethyl phosphorodithioate; S-(N-Formyl-N-methylcarbamoylmethyl) O,O-dimethyl phosphorodithioate; S-(N-Formyl-N-methylcarbamoylmethyl) dimethyl phosphorothiolothionate; SAN 244 I; SAN 6913 I; SAN 7107 I; Sandoz S-6900; Spencer S-6900; Toprose; VEL 4284; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellow liquid; mp = 25 deg C; [Hawley] Pale yellow liquid or solid; mp = 25-26 deg C; [HSDB] Colorless to pale yellow liquid or solid; mp = 25-26 deg C; [MSDSonline]

Sources/Uses

Used as acaricide and systemic insecticide; [Merck Index] Not currently commercially produced in the US; Likely discontinued for pesticide use worldwide; [HSDB]

Comments

Not irritating to rabbit eyes; Effects in high dose animal studies include inhibition of cholinesterase activity, minor histological changes to liver and adrenal glands, functional changes of the liver, and hematological changes; No evidence of skin sensitization, increased tumor incidence, other neurotoxicity, nor developmental or teratogenic toxicity [HSDB] No significant adverse gross or histological changes or increase in tumor frequency observed in two year feeding studies with rats and dogs; [INCHEM JMPR] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

8.48E-07 mm Hg

LC50 (rat) = 4,500 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)