Fumonisin B1
Agent Name
Fumonisin B1
CAS Number
116355-83-0
Formula
C34-H59-N-O15
Major Category
Biological Agents
Synonyms
Macrofusine; 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester; [ChemIDplus]
Category
Mycotoxins
Description
White hygroscopic solid; [HSDB] Light brownish-yellow solid; [MSDSonline]
Sources/Uses
Most common member of a family of mycotoxins produced by Fusarium moniliforme, a common corn mold; [Merck Index]
Comments
Causes abnormal liver function tests after subcutaneous doses in mice; [RTECS] Causes increased liver cancer in rats; [IARC] Interferes with sphingolipid metabolism in animals causing leukoencephalomalacia in horses and rabbits, pulmonary edema and hydrothorax in swine, and hepatotoxicity and liver cancer in rats; It is probably linked with esophageal cancer in humans exposed to moldy corn meal and grits; [Reference #2]
Reference Link #1
Biomedical References
Exposure Assessment
Reference Link #2
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Possible (2b)
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.