Grayanotoxin I
Agent Name
Grayanotoxin I
CAS Number
4720-09-6
Formula
C22-H36-O7
Major Category
Biological Agents
Synonyms
7,9a-Methano-9aH-cyclopenta(b)heptalene-2,4,8,11,11a,12(1H)-hexol-, dodecahydro-1,1,4,8-tetramethyl-, 12-acetate, (2S,3aS,4R,4aR,7R,8R,9aS,11R,11aR,12R)-; Acetylandromedol; Andromedotoxin; Asebotoxin; G-I; GTX-I; Grayanotoxane-3,5,6,10,14,16-hexol 14-acetate; Perhydro-2beta,4alpha,8alpha,11beta,11abeta-pentahydroxy-1,1,4,8-tetramethyl-7,9a-methano-9aalphaH-cyclopenta(b)heptalen-12beta-yl acetat; Rhodotoxin; Rhodotoxine; [ChemIDplus]
Category
Plant Toxins
Description
Solid; [Merck Index]
Sources/Uses
Toxic diterpenoid found in the leaves of different Rhododendron, Kalmia, and Leucothoe species and in rhododendron flower honey; [Merck Index] Used for physiological research; [HSDB] Toxin found in Azalea, Heath, Ivy bush, Lily-of-the-valley bush, Mad honey, Mock azalea, Mountain laurel, Rhododendron, and Rustyleaf; [Olson, p. 376-89]
Comments
Emergency treatment: "Plants- Grayanotoxins"; Prognosis is excellent with supportive care and treatment of hypotension and dysrhythmias; Toxicity may occur after eating 10 azalea blossoms or 50-75 ml of honey made by bees eating nectar of rhododendrons or other plants of the Ericaceae family; [HSDB] Symptoms after ingestion include paresthesias, vomiting, hypotension, bradycardia, seizures, and coma; [Olson, p. 376]
Biomedical References
Exposure Assessment
Vapor Pressure
2.3E-14 mm Hg
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.