(Hydroxyimino)cyclohexane

Agent Name
(Hydroxyimino)cyclohexane
CAS Number
100-64-1
Formula
C6-H11-N-O
Major Category
Nitrogen Compounds
(Hydroxyimino)cyclohexane formula graphical representation
Synonyms
Antioxidant D; Cyclohexanone oxime; Cyclohexanone, oxime; [ChemIDplus]
Category
Oximes
Description
Solid; [HSDB] Liquid or light tan solid; mp = 89-91 deg C; [CAMEO] White chunks or powder; [Alfa Aesar MSDS]
Sources/Uses
Used to make caprolactam; [HSDB] A closed-system intermediate (CSI); [EPA ChAMP: Screening Level Hazard Characterization] Used in coatings; [ECHA REACH Registrations]
Comments
Mixtures of cyclohexanone and oxime (varying ratios) produced anesthesia, conjunctivitis, and increased aggression in oral studies of rats; Emergency treatment: Methemoglobinemia; [HSDB] May peroxidize; [CAMEO] Increased methemoglobin levels observed in dermal lethal-dose study or rabbits; Progressive anemia with increased splenic hemosiderin deposition and hematopoiesis observed in 90-day gavage study of rats; No changes in sperm motility or vaginal cytological parameters seen; Limited evidence of mutagenicity in vitro and no evidence in vivo; A major metabolite, cyclohexanone (CAS # 108-94-1), caused reduced fetal body weight and increased frequency of retardation of ossification at levels maternally toxic in inhalation study of rats (LOAEL for maternal and developmental toxicity both equal 5,600 mg/m3/day); [EPA ChAMP: Screening Level Hazard Characterization] A strong eye irritant; Harmful by ingestion; Prolonged or repeated ingestion exposure may cause injury to the hematopoietic system; [ECHA REACH Registrations] An irritant; Toxic by ingestion; [Alfa Aesar MSDS]
Biomedical References

Exposure Assessment

Adverse Effects

Methemoglobinemia
MetHgb is secondary toxic effect

Diseases, Processes, and Activities Linked to This Agent

Processes

Industrial Processes with risk of exposure: