o-Methylcyclohexanone

Synonyms

2-Methyl-1-cyclohexanone; 2-Methyl-cyclohexanon [German, Dutch]; 2-Methylcyclohexanone; 2-Metilcicloesanone [Italian]; Methylanon; Sexton B; alpha-Methylcyclohexanone; o-Methylcyclohexanone; [ChemIDplus] UN2297

Category

Ketones (<C12)

Description

Colorless liquid with a weak, peppermint-like odor; [NIOSH]

Sources/Uses

Used as a rust remover and a solvent to make lacquers, varnishes, and plastics; [ACGIH]

Comments

TLV Basis is liver effects and CNS impairment. TLV-TWA is 20 ppm for Methylcyclohexanone (mixture of the 3 isomers), CAS number 1331-22-2. Causes liver toxicity in feeding study of rats. [ACGIH] A skin, eye, and respiratory tract irritant; [CAMEO]

Biomedical References

Yes

20 ppm

100 ppm

600 ppm

Excerpts from Documentation for IDLHs

Other animal data: Mice, guinea pigs, and rats exposed at 3,500 ppm for 30 minutes suffered irritation of the mucous membranes and exhibited signs of central nervous system depression [Clayton and Clayton 1981]. Rabbits and cats exhibited sleepiness, respiratory irregularities, and poor coordination after a 1­hour exposure to 2,500 ppm [Clayton and Clayton 1981].

2.25 mm Hg

0.5 ppm

LCLo (rat) = 2,800 ppm/4H

Explanatory Notes

Flash point = 118 deg F; Odor threshold from CHEMINFO;

high ambient temp required

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)
• Plastic Composites Manufacturing