Isazofos

Synonyms

A-12223; Brace; CGA-12223; Ciba 12223; Isazophos; Miral; Miral 10 G; O-(5-Chloro-1-(1-methylethyl)-1H-1,2,4-triazol-3-yl) O,O-diethyl phosphorothioate; O-(5-Chloro-1-isopropyl-1H-1,2,4-triazol-3-yl) O,O-diethylphosphorothioate; O-5-Chloro-1-isopropyl-1H-1,2,4-triazol-3-yl O,O-diethyl phosphorothioate; Triumph; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellow or amber liquid; [HSDB]

Sources/Uses

Used as insecticide for turf, maize, rice, and other crops; Also used as soil nematicide for bananas, citrus, and other annual crops; [HSDB]

Comments

Caused inhibition of cholinesterase activity but no gross or histopathological changes observed in long term feeding studies with rats and dogs; No evidence of increase in tumor frequency in long term feeding studies with rats; Caused developmental toxicity in rats at dose levels maternally toxic; No evidence of delayed neurotoxicity in oral studies with birds; No evidence of any mutagenic effects from the California EPA (2003); Marked increase in spontaneous mutation frequency observed with Salmonella and increase in mitotic indices and chromosome aberrations seen in bone marrow cells of mice (Mutation Research in Amsterdam 1998); [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

No longer registered as a pesticide for use in the US; [HSDB]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

8.7E-05 mm Hg

LC50 (rat) = 103 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)