p-Nitroaniline

Synonyms

1-Amino-4-nitrobenzene; 4-Nitraniline; 4-Nitroaniline; 4-Nitrobenzenamine; Aniline, 4-nitro-; Aniline, p-nitro-; Azoamine Red ZH; Azofix Red GG Salt; Azoic Diazo Component 37; Benzenamine, 4-nitro-; C.I. 37035; C.I. Azoic Diazo Component 37; C.I. Developer 17; CI 37035; CI Azoic Diazo Component 37; CI Developer 17; Developer P; Devol Red GG; Diazo Fast Red GG; Fast Red 2G Base; Fast Red 2G Salt; Fast Red Base 2J; Fast Red Base GG; Fast Red GG Base; Fast Red GG Salt; Fast Red MP Base; Fast Red P Base; Fast Red P Salt; Fast Red Salt 2J; Fast Red Salt GG; Naphtoelan Red GG Base; Nitrazol CF Extra; PNA; PNA (VAN); Red 2G Base; Shinnippon Fast Red GG Base; p-Aminonitrobenzene; p-Nitraniline; p-Nitroanilina [Polish]; p-Nitroaniline; p-Nitrophenylamine; para-Aminonitrobenzene; para-Nitroaniline; [ChemIDplus] UN1661

Category

Nitroanilines

Description

Bright yellow, crystalline powder with a slight ammonia-like odor; [NIOSH]

Sources/Uses

Used in the production of dyes, antioxidants, gasoline gum inhibitors, and corrosion inhibitors; [ACGIH]

Comments

Can cause severe methemoglobinemia in the workplace; Chronic exposure can cause anemia, jaundice, and liver injury; Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A mild eye irritant; May induce methemoglobinemia; [ICSC]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

3 mg/m3

6 mg/m3

300 mg/m3

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH (300 mg/m3 or 50 ppm) is based on an analogy with aniline and the statement by AIHA [1955] that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m3) chosen for p­nitroaniline is reasonable because Von Oettingen [1941] stated that p­nitroaniline is more toxic than aniline. . . . Human data: None relevant for use in determining the revised IDLH

3.2E-06 mm Hg

Explanatory Notes

Flash point = 199 deg C; VP from HSDB;

must be preheated

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Methemoglobinemia, acute