N-Isopropyl-N'-phenyl-p-phenylenediamine

Synonyms

4-(Isopropylamino)diphenylamine; 1,4-Benzenediamine, N-(1-methylethyl)-N'-phenyl-; 4-Anilino-N-isopropylaniline; 4-Isopropylaminodiphenylamine; 4010 NA; 4010NA; ASM 4010MA; Antigen 3c; Antigene 3C; Antioxidant 4010 NA; Antioxidant 4010NA; Antioxidant 40NA; Antioxidant IP; Cyzone; Cyzone IP; Diafen FP; Diaphen FP; Elastozone 34; Flexzone 3C; IPPD; Ipognox 44; N-2-Propyl-N'-phenyl-p-phenylenediamine; N-Fenyl-N'-isopropyl-p-fenylendiamin [Czech]; N-Isopropyl-N'-fenyl-p-fenylendiamin [Czech]; N-Isopropyl-N'-phenyl-4-phenylenediamine; N-Isopropyl-N'-phenyl-para-phenylenediamine; N-Phenyl-N'-isopropyl-1,4-phenylenediamine; N-Phenyl-N'-isopropyl-p-phenylenediamine; NA 4010; Nocrac 810NA; Nocrack 810NA; Nonox ZA; Orflex PP; Ozonon 3C; Permanax 115; S-IP; Santoflex 36; Santoflex IP; p-Phenylenediamine, N-isopropyl-N'-phenyl-; para-Isopropylaminodiphenylamine; Benzenediamine, N-(1-methylethyl)-N'-phenyl-, 1,4-; [ChemIDplus] IPPD; [HSDB]

Category

Amines, Polyaromatic

Description

Dark grey to black solid; [Hawley] Brown, grey, or dark purple to black solid; [CHEMINFO]

Sources/Uses

Used to protect rubber against oxidation, ozone, and contamination by copper and manganese; [Hawley] Occupational exposures are mainly to rubber tires; [Kanerva, p. 1805]

Comments

A skin and eye irritant; May cause skin sensitization; [ICSC] Emergency treatment: "Paraphenylenediamine"; Paraphenylenediamine can cause angioneurotic edema, the most common cause of death after an overdose; Other effects after ingestion are vomiting, acute tubular necrosis, liver injury, methemoglobinemia, and seizures; p-Phenylenediamine is a skin and respiratory tract sensitizer; [HSDB] A skin, eye, and respiratory tract irritant; May cause contact dermatitis; [CAMEO] Does not readily penetrate intact skin; Not an eye or skin irritant based on animal studies; May cause skin sensitization; No data available on inhalation toxicity, respiratory sensitization, or carcinogenicity; [OECD SIDS: N-Isopropyl-N'-phenyl-p-phenylenediamine (IPPD) - 2000] See "p-Phenylenediamine."

Biomedical References

2 mg/m3, inhalable fraction

7.11E-05 mm Hg

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic