Major Category
Biological Agents
Synonyms
2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone; 2H-Furo(2,3-H)-1-benzopyran-2-one; 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; Angecin; Angelicin (coumarin derivative); Furo(2,3-h)coumarin; Furo(5',4':7,8)coumarin; Isopsoralen; Angelicin plus ultraviolet A radiation [Angelicins]; [ChemIDplus]
Description
Solid; [MSDSonline]
Sources/Uses
Found in many plants traditionally used as herbal remedies; Highly fluorescent; [HSDB] Present in plants of the Umbelliferae family; Clinically tested in combination with ultraviolet A radiation for the treatment of psoriasis; [IARC]
Comments
May cause photosensitization; Emergency treatment: "Psoralens"; Therapeutic doses (with UV light) are 0.6 mg/kg; Hepatitis has been reported after ingestion of herbal remedies and use of psoralen-UV therapy; [HSDB] Causes changes in liver weight and liver enzymes in feeding studies of mice; Causes altered sleep and ataxia in lethal dose feeding studies of rats; [RTECS] An irritant; Can cause photosensitization; [Aldrich MSDS]
Vapor Pressure
2.24E-05 mm Hg
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
PICD (photoirritant contact dermatitis)
IARC Carcinogen
Not classifiable
Diseases
Occupational diseases associated with exposure to this agent: