Angelicin

Agent Name
Angelicin
CAS Number
523-50-2
Formula
C11-H6-O3
Major Category
Biological Agents
Angelicin formula graphical representation
Synonyms
2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone; 2H-Furo(2,3-H)-1-benzopyran-2-one; 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; Angecin; Angelicin (coumarin derivative); Furo(2,3-h)coumarin; Furo(5',4':7,8)coumarin; Isopsoralen; Angelicin plus ultraviolet A radiation [Angelicins]; [ChemIDplus]
Category
Plant Toxins
Description
Solid; [MSDSonline]
Sources/Uses
Found in many plants traditionally used as herbal remedies; Highly fluorescent; [HSDB] Present in plants of the Umbelliferae family; Clinically tested in combination with ultraviolet A radiation for the treatment of psoriasis; [IARC]
Comments
May cause photosensitization; Emergency treatment: "Psoralens"; Therapeutic doses (with UV light) are 0.6 mg/kg; Hepatitis has been reported after ingestion of herbal remedies and use of psoralen-UV therapy; [HSDB] Causes changes in liver weight and liver enzymes in feeding studies of mice; Causes altered sleep and ataxia in lethal dose feeding studies of rats; [RTECS] An irritant; Can cause photosensitization; [Aldrich MSDS]
Biomedical References

Exposure Assessment

Vapor Pressure
2.24E-05 mm Hg

Adverse Effects

Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
PICD (photoirritant contact dermatitis)
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: