Angelicin

Synonyms

2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone; 2H-Furo(2,3-H)-1-benzopyran-2-one; 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; Angecin; Angelicin (coumarin derivative); Furo(2,3-h)coumarin; Furo(5',4':7,8)coumarin; Isopsoralen; Angelicin plus ultraviolet A radiation [Angelicins]; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [MSDSonline]

Sources/Uses

Found in many plants traditionally used as herbal remedies; Highly fluorescent; [HSDB] Present in plants of the Umbelliferae family; Clinically tested in combination with ultraviolet A radiation for the treatment of psoriasis; [IARC]

Comments

May cause photosensitization; Emergency treatment: "Psoralens"; Therapeutic doses (with UV light) are 0.6 mg/kg; Hepatitis has been reported after ingestion of herbal remedies and use of psoralen-UV therapy; [HSDB] Causes changes in liver weight and liver enzymes in feeding studies of mice; Causes altered sleep and ataxia in lethal dose feeding studies of rats; [RTECS] An irritant; Can cause photosensitization; [Aldrich MSDS]

Biomedical References

2.24E-05 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

PICD (photoirritant contact dermatitis)

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, photoirritant