1-Nitropropane

Synonyms

1-NP; 1-Nitropropane; [ChemIDplus] UN2608

Category

Nitros, Aliphatic

Description

Colorless liquid with a somewhat disagreeable odor; [NIOSH]

Sources/Uses

Used in organic chemical synthesis and as a rocket propellant, gasoline additive, and solvent; [ACGIH] Used as a solvent for waxes, resins, lacquers, synthetic rubber, fats, oils, dyes, inks, and other organic materials; [HSDB]

Comments

A hepatotoxin in animals after oral administration or inhalation; [ACGIH] An eye and respiratory tract irritant; [ICSC] Volunteers tolerated 100 ppm for 8 hours; 150 ppm caused irritation of the nose and throat; A weak inducer of methemoglobinemia; [CHEMINFO] Causes CNS depression and anesthesia in lethal concentration animal studies; [ChemIDplus] See "2-Nitropropane."

Biomedical References

Insufficient data

25 ppm

25 ppm

2 ppm

1000 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rabbits survived a 1­hour exposure to 10,000 ppm [Machle et al. 1940]. Human data: Volunteers found brief exposures to concentrations exceeding 100 ppm to cause eye irritation [Silverman et al. 1946].

10.1 mm Hg

7.7 ppm

Odor Threshold High

140 ppm

LC50 (rat) = 3,100 ppm/8H

Explanatory Notes

Detection odor threshold from AIHA (mean = 140 ppm); Flash point = 36 deg C; VP from HSDB;

may ignite at ambient temp

MetHgb is secondary toxic effect

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not Classifiable

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)
• Plastic Composites Manufacturing
• Semiconductor Manufacturing