Linalyl acetate

Synonyms

1,6-Octadien-3-ol, 3,7-dimethyl-, acetate; 3,7-Dimethyl-1,6-octadien-3-ol acetate; 3,7-Dimethyl-1,6-octadien-3-yl acetate; Acetic acid linalool ester; Bergamiol; Bergamol; Bergamot mint oil; Ex bois de rose (synthetic); Licareol acetate; Linalol acetate; Linalool acetate; Linalyl acetate (natural); Lynalyl acetate; [ChemIDplus]

Category

Plant Oils and Extracts

Description

Clear colorless liquid with an odor of bergamot; [Hawley]

Sources/Uses

Present in bergamot, lavender, and other volatile oils; [Merck Index] Used in perfumes, soaps, cleaning products, cosmetics, oil paints, and flavoring extracts; [HSDB]

Comments

Emergency treatment: "Linalool"; [HSDB] Included in list of "established contact allergens in humans"; [EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] Causes somnolence and ataxia and acts as a general anesthetic in lethal dose studies of rats; [RTECS] Safe when used as a flavoring agent in food; [JECFA] Hydrolyzed in the GI tract into linalool and acetic acid; Not a mutagen; Not likely to be a sensitizer; Linalool, a hydrolysis product, caused "hepatocellular cytoplasmic vacuolisation" in 28-day feeding studies of rats; [Reference #1] See "Linalool."

Reference Link #1

Biomedical References

0.111 mm Hg

6.06 ppm

LC50 (mice) > 1,028 mg/m3/4h

Explanatory Notes

Odor threshold from CHEMINFO;

Reference Link #2

high ambient temp required

Yes

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)