Phosphorus oxychloride

Synonyms

Fosforoxychlorid [Czech]; Oxychlorid fosforecny [Czech]; Phosphoric trichloride; Phosphoroxychloride; Phosphorus chloride oxide (POCl3); Phosphorus oxide trichloride; Phosphorus oxychloride; Phosphorus oxytrichloride; Phosphoryl chloride; Phosphoryl trichloride; Trichlorophosphine oxide; Trichlorophosphorus oxide; [ChemIDplus] UN1810

Category

Acid Halides

Description

Clear, colorless to yellow, oily liquid with a pungent & musty odor. [Note: A solid below 34 degrees F.]; [NIOSH]

Sources/Uses

Used in chemical synthesis as a chlorinating agent and catalyst and to produce plasticizers, hydraulic fluids, gasoline additives, and fire retardants; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Highly corrosive to skin; [Quick CPC] Mucous membrane irritation, bronchitis, pulmonary edema, and nephritis have been reported after occupational exposure. [ACGIH] Liver injury in animals in a chronic study; [Desai, H. Phosphorus and Phosphorus Compounds. In: Sullivan J, Krieger G (eds). Hazardous Materials Toxicology. Baltimore:Williams & Wilkins,1992;939] A corrosive substance that can cause pulmonary edema; [ICSC] A lachrymator; [CHEMINFO]

Biomedical References

Insufficient data

Yes

0.1 ppm

Yes

0.02 ppm

LC50 (rat) = 32 ppm/4h

Explanatory Notes

VP = 40 mmHg @ 81 deg F; [Sax] Some “Water Reactive Materials” are also TIH materials themselves: Phosphorus oxychloride; [ERG 2016]

Reference Link #2

will not burn

Yes

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Pneumonitis, toxic

Processes

Industrial Processes with risk of exposure:

• Semiconductor Manufacturing
• Toxic Gas from Spilling Chemical in Water