Methanesulfonyl fluoride

Synonyms

Fluoro methyl sulfone; Fumette; MSF; Mesyl fluoride; Methanesulphonyl fluoride; [ChemIDplus] UN2927

Category

Acid Halides

Description

Liquid; [CAMEO] Colorless liquid with a pungent odor; [MSDSonline]

Sources/Uses

Used formerly as fumigant insecticide; Used in medical research; [HSDB]

Comments

Highly corrosive; May cause serious injury to skin, eyes, mucous membranes, and upper respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; A selective inhibitor of CNS acetylcholinesterase; Sex-specific changes in brain development were observed in rats chronically exposed in utero; [HSDB] Reacts with water evolving hydrogen fluoride gas; Corrosive; Highly toxic by inhalation; [CAMEO] Effects in high-dose animal studies include inhibition of true cholinesterase and degenerative changes to brain; [RTECS]

Biomedical References

Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

2.5 mg/m3, as F

2.5 mg/m3, as F

1 mg/m3, as F, inhalable fraction

10.9 mm Hg

LC50 (rat) = 1 ppm/7h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic liquid, corrosive, organic, n.o.s. (Inhalation Hazard Zone A)." VP from ChemIDplus;

Yes

Skin burns

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)