Diethylenediamine dihydrochloride; Dihydro Pip Wormer; Dihydrochloride salt of diethylenediamine; Dowzene DHC; Piperazine dihydrochloride; Piperazine wormer premix; [ChemIDplus]
White to cream-colored needles or powder; [NIOSH]
Used to manufacture fibers, pharmaceuticals, and insecticides; [ACGIH] Used as a veterinary anthelmintic medication and a curing agent for polychloroprene; [HSDB]
Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers; [Malo] Allergic contact dermatitis reported in pharmaceutical, laboratory, healthcare, and veterinary workers; [Kanerva, p. 1827] See "Piperazine and salts."
TLV withdrawn 2012;
Occupational diseases associated with exposure to this agent:
Industrial Processes with risk of exposure: