Propargyl alcohol

Synonyms

1-Propyn-3-ol; 2-Propyn-1-ol; 2-Propynyl alcohol; [NIOSH]

Category

Other Toxic Gases & Vapors

Description

Colorless to straw-colored liquid with a mild, geranium odor; [NIOSH]

Sources/Uses

Used in steel and chemical production; Also used as a solvent stabilizer, fumigant, and corrosion inhibitor; [ACGIH]

Comments

Liquid causes second degree burns after contact for a few minutes. [CHRIS] Toxic to liver and kidneys in rats after repeated exposure to concentrations of 80 ppm; TLV Basis: Eye irritation and liver & kidney damage; "A TLV–TWA of 1 ppm (2.3 mg/m3) is recommended for occupational exposure to propargyl alcohol, based on the structural and apparent toxicological similarity to allyl alcohol . . . " [ACGIH] A lachrymator; [CHEMINFO] See "Allyl alcohol."

Biomedical References

Yes

1 ppm

2 ppm

15.6 mm Hg

0.15 ppm

LC50 (rat) = 1040 ppm/1 hr;

Explanatory Notes

Odor threshold from CHEMINFO; Flash point = 97 deg F; [CHEMINFO] VP from HSDB;

may ignite at ambient temp

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Fumigants, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)
• Semiconductor Manufacturing
• Steel Producing