N-Phenylhydroxylamine
Agent Name
N-Phenylhydroxylamine
CAS Number
100-65-2
Formula
C6-H7-N-O
Major Category
Nitrogen Compounds
Synonyms
Aniline, N-hydroxy-; Benzenamine, N-hydroxy-; Benzene, hydroxylamino-; Hydroxylamine, N-phenyl-; N-Hydroxyaniline; N-Hydroxybenzenamine; Phenylhydroxyamine; Phenylhydroxylamine; [ChemIDplus]
Category
Hydroxylamines
Description
Solid; [Merck Index] Tan to brown solid; [CAMEO]
Sources/Uses
Used as intermediate for cupferron and p-aminophenol; Not commercially produced in the US; [HSDB]
Comments
Occupational cases of severe poisoning have been reported; Markedly increases sister chromatid exchange in cultured human fibroblasts; Causes methemoglobinemia in rats and mice; Lethal-dosed rats did not exhibit methemoglobin levels sufficiently high to cause death by anoxia, suggesting that methemoglobinemia is not responsible for acute toxicity; Emergency treatment: Methemoglobinemia; [HSDB] An irritant; [CAMEO] Irritating to human skin; Causes hematuria and methemoglobinemia in subcutaneous, lethal-dose studies of rats and rabbits; Repeated dose studies of rats produce weight loss and changes to blood; [RTECS] May cause irritation; [Aldrich MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
0.00795 mm Hg
Explanatory Notes
VP from ChemIDplus;
Adverse Effects
Methemoglobinemia
MetHgb is primary toxic effect
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: