Nicarbazin

Synonyms

4,4'-Dinitrocarbanilide, compd. with 4,6-dimethyl-2-pyrimidinol; MK 75; MK 75 (VAN); N,N'-Bis(4-nitrophenyl)urea compd. with 4,6-dimethyl-2-pyrimidinol (1:1); Nicarb; Nicarbasin; Nicarbazine; Nicoxin; Nicrazin; Nicrazine; Nirazin; 1,3-Bis(4-nitrophenyl)urea-4,6-dimethylpyrimidin-2-ol; Carbanilide, 4,4'-dinitro-, compd. with 4,6-dimethyl-2-pyrimidinol (1:1); Urea, N,N'-bis(4-nitrophenyl)-, compd. with 4,6-dimethyl-2(1H)-pyrimidinone (1:1); [ChemIDplus]

Category

Animal Feed Additives

Description

Light yellow solid; [HSDB]

Sources/Uses

Used as a coccidiostat for poultry and to reduce egg hatching in resident Canadian geese; [HSDB]

Comments

An equimolar complex of 4,4'-dinitrocarbanilide and 2-hydroxy-4,6-dimethylprimidine; A moderate eye irritant; Oral LD50 (rat) >10,000 mg/kg; In high-dose feeding studies of dogs over 2 years, it caused liver injury in doses >240 mg/kg/day; In another animal study, the NOEL for maternal and fetal toxicity was 200 mg/kg/day; [HSDB] An irritant; [MSDSonline]

Reference Link #1

Biomedical References

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Processes

Industrial Processes with risk of exposure:

• Farming (Feed Additives)
• Farming (Pesticides)