1,1,1,2-Tetrachloro-2,2-difluoroethane
Agent Name
1,1,1,2-Tetrachloro-2,2-difluoroethane
Synonyms
1,1-Difluoro-1,2,2,2-tetrachloroethane; 1,1-Difluoroperchloroethane; 2,2-Difluoro-1,1,1,2-tetrachloroethane; 2,2-Difluorotetrachloroethane; CFC 112a; Ethane, 1,1-difluoro-1,2,2,2-tetrachloro-; F 112a; Fluorocarbon 112a; Halocarbon 112a; R 112a; Refrigerant 112a; [ChemIDplus]
Category
Chlorofluorocarbons
Description
Colorless solid with a slight, ether-like odor. [Note: A liquid above 105 degrees F]; [NIOSH]
Sources/Uses
CFC-112a has been used as a refrigerant. [ACGIH] "Use in dry cleaning industry; in polymer & plastics industry as blowing or foaming agent; as solvent extractor for separation & purification of biological material; as a dye solvent to give brighter colors and to detect surface cracks or defects in metals; as a corrosion inhibitor."; [HSDB]
Comments
Rats exposed to 10,000 ppm for 2 hours show signs of intoxication. At 20,000 to 30,000 ppm, all rats die within 1.5 to 2 hours. There are signs of kidney and liver injury, but no signs of pulmonary injury. [ACGIH] See "CHLOROFLUOROCARBONS";
Restricted
See CHLOROFLUOROCARBONS
Skin Designation (ACGIH)
Insufficient data
Excerpts from Documentation for IDLHs
Other animal data: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while a concentration of 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950].
Lethal Concentration
LCLo (rat) = 20,000 ppm/30 min
Explanatory Notes
VP from HSDB;
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases
Occupational diseases associated with exposure to this agent: