Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3,6)-sulfide; Phalloidine; [ChemIDplus] UN3462
White solid; [MSDSonline]
A toxin from the poisonous green fungus Amanita phalloides; [Merck Index] Used for physiological studies; [HSDB]
10 to 20 times less toxic than alpha-amanitin, but faster acting; [Merck Index] Intraperitoneal LD50 (mouse) = 2 mg/kg; [RTECS] "Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage." [ChemIDplus] Emergency treatment: "Mushrooms- cyclopeptides"; [HSDB] May cause irritation; May be fatal by inhalation, skin absorption, and ingestion; Targets the kidneys and liver; Unlike amanitin poisoning, which may be delayed for 12 to 24 hours, phalloidin can be fatal in 1 to 2 hours; [Aldrich MSDS] See "alpha-Amanitin."
The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."
Other CNS neurotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
No other related information on this agent was found.