Phosalone

Synonyms

Agria 1060 A; 11 974 RP; 3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl O,O-diethyl phosphorothiolothionate; 3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl-O,O-diethyl phosphorothiolothionate; 3-(O,O-Diethyldithiophosphorylmethyl)-6-chlorobenzoxazolinone; 3-(O,O-Diethyldithiophosphorylmethyl)-6-chlorobenzoxazolone; 3-Diethyldithiophosphorylmethyl-6-chlorobenzoxazolone-2; 6-Chloro-3-(O,O-diethyldithiophosphorylmethyl)benzoxazolone; 6-Chloro-3-diethoxyphosphinothioylthiomethyl-1,3-benzoxazol-2(3H)-one; Agria 1060; Azofene; Benzophosphate; Benzphos; Chipman 11974; ENT 27,163; Fosalon; Fozalon; NIA-9241; NPH-1091; Niagara 9241; O,O-Diaethyl-S-(6-chlor-2-oxo-ben(b)-1,3-oxalin-3-yl)-methyl-dithiophosphat [German]; O,O-Diethyl S-((6-chloro-2-oxobenzoxazolin-3-yl)methyl) phosphorodithioate; O,O-Diethyl phosphorodithioate, S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone; O,O-Diethyl-S-((6-chloor-2-oxo-benzoxazolin-3-yl)-methyl)-dithiofosfaat [Dutch]; O,O-Diethyl-S-(6-chloro-2-oxo-benzoxazolin-3-yl)methyl-phosphorothiolothionate; O,O-Diethyl-S-(6-chloro-2-oxobenzoxazolin-3-yl-methyl)-phosphorodithioate; O,O-Diethyl-S-(6-chlorobenzoxazonyl-3-methyl) dithiophosphate; O,O-Dietil-S-((6-cloro-2-oxo-benzossazolin-3-il)-metil)-ditiofosfato [Italian]; P 974; P-974; Phosalon; Phosalone 35 EC; Phosphorodithioic acid, O,O-diethyl ester, S-ester with 6-chloro-3-(mercaptomethyl)-2-benzoxazolinone; Phosphorodithioic acid-S-ester of 6-chloro-3-mercaptomethylbenzoxazyol-2-one; Phozalon; RP 11,974; Rhodia RP 11974; Rubitox; S-((3-Benzoxazolinyl-6-chloro-2-oxo)methyl) O,O-diethyl phosphorodithioate; S-((6-Chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl phosphorodithioate; S-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl diethyl phosphorothiolothionate; S-(6-Chloro-3-(mercaptomethyl)-2-benzoxazolinone) O,O-diethyl phosphorodithioate; S-6-Chloro-2,3-dihydro-2-oxo-1,3-benzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate; S-6-Chloro-2,3-dihydro-2-oxo-benzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate; Zolone; Zolone DT; Zolone PM; Zone; [ChemIDplus] UN2783

Category

Organophosphate Insecticides

Description

Colorless or white solid; [ICSC] Odor like garlic; [HSDB] White crystals; [MSDSonline]

Sources/Uses

Used as insecticide and acaricide for fruits, vegetables, ornamentals, and other crops; Still used in many countries; [HSDB] Import tolerances for almonds, grapes, apples, and other fruits grown in countries with active registrations; [Reference #1]

Comments

A skin, eye, and respiratory tract irritant; Can be absorbed through skin; A weak cholinesterase inhibitor; [ICSC] Effects in animal studies include zonal hepatitis; [RTECS] May cause skin sensitization; [eChemPortal: ESIS] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Cancelled--no longer registered as a pesticide for use in the US; [HSDB] Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

4.54E-08 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)