Propaphos

Synonyms

4-Methylthiophenyl dipropyl phosphate; Kayaphos; Kayphosnac; NK-1158; O,O-Di-n-propyl-O-(4-methylthiophenyl)phosphate; Phosphoric acid, dipropyl 4-methylthiophenyl ester; Propafos [ISO-French]; Phosphoric acid, 4-(methylthio)phenyl dipropyl ester; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless liquid; [HSDB] Yellowish liquid with a stench; [MSDSonline]

Sources/Uses

Used as systemic insecticide for rice; [HSDB]

Comments

Inhibited serum and erythrocyte cholinesterase activity in study with rats; [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Not commercially produced or used in the US; Likely discontinued for pesticide use worldwide (may still have active registrations in Japan and Taiwan); [HSDB]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

9E-07 mm Hg

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)