Pyriminil

Synonyms

1-(3-Pyridylmethyl)-3-(4-nitrophenyl)urea; 1-(4-Nitrophenyl)-N'-(3-pyridinylmethyl)urea; DLP 787; N-(4-Nitrophenyl)-N'-(3-pyridinylmethyl)urea; N-3-Pyridylmethyl-N'-p-nitrophenylurea; One Time; PNU; Pyriminyl; Pyrinuron; Pyrinuron [ANSI]; RH-787; Vacor; Urea, 1-nitrophenyl-3-(3-pyridylmethyl)-; Urea, N-(4-nitrophenyl)-N'-(3-pyridinylmethyl)-; [ChemIDplus]

Category

Rodenticides

Description

Yellow or yellow-green solid; [HSDB] Light yellow flakes; [MSDSonline]

Sources/Uses

Used as rodenticide; Very effective on rodents resistant to anticoagulants; Commercial distribution voluntarily suspended by Rohm and Haas Co. in 1979 following many reported human poisonings; [HSDB] Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. [Wikipedia]

Comments

Destroys pancreatic beta cells; In human poisoning cases after ingestion, caused orthostatic hypotension, autonomic dysfunction, encephalopathy, peripheral neuropathy, hyperglycemia, and ketoacidosis; Systemic poisoning not reported after inhalation or skin absorption; A dose as low as 19 grams may be fatal; [HSDB] Humans who survive poisoning have developed insulin-dependent diabetes mellitus; [CAMEO]

No longer registered with the EPA for use in the US; [HSDB]

Biomedical References

3.39E-09 mm Hg

Other CNS neurotoxin

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)