Chlorodifluoromethane
Agent Name
Chlorodifluoromethane
Alternative Name
Refrigerant 22
CAS Number
75-45-6
Formula
C-H-Cl-F2
Major Category
Solvents
Synonyms
Refrigerant 22; Algeon 22; Algofrene 22; Algofrene type 6; Arcton 22; Arcton 4; CFC 22; Chlorofluorocarbon 22; Daiflon 22; Difluorochloromethane; Difluoromonochloromethane; Dymel 22; Electro-CF 22; Eskimon 22; F 22; F 22 (halocarbon); FC 22; FKW 22; Flugene 22; Fluorocarbon-22; Forane 22; Forane 22 B; Freon 22; Frigen; Frigen 22; Genetron 22; HCFC 22; HFA-22; Haltron 22; Hydrochlorofluorocarbon 22; Isceon 22; Isotron 22; Khladon 22; Methane, chlorodifluoro-; Monochlorodifluoromethane; Propellant 22; R 22 (refrigerant); R-22; Racon 22; Refrigerant R 22; Ucon 22; [ChemIDplus] UN1018
Category
Chlorofluorocarbons
Description
Colorless gas with a faint, sweetish odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]
Sources/Uses
Used as a propellant, a refrigerant, a solvent, and in tetrafluoroethylene polymers; [ACGIH]
Comments
When inhaled by guinea pigs, narcosis occurs at 200,000 ppm and death at 300,000 ppm. [ACGIH] Possible frostbite from contact with liquid; [NIOSH] Chlorodifluoromethane is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] Evaporating liquid can cause frostbite; Inhalation of high concentrations can cause CNS depression and cardiac arrhythmias; [ICSC]
Restricted
See CHLOROFLUOROCARBONS
Reference Link #1
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
1000 ppm
MAK
500 ppm
Lethal Concentration
LC50 (rat) = 350,000 ppm/15m
Adverse Effects
Neurotoxin
Acute solvent syndrome
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Not Classifiable
Other Poison
Simple Asphyxiant
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: