1,4-Benzenediamine sulfate

Synonyms

p-Phenylenediamine sulfate; Benzene-1,4-diammonium sulphate; [ChemIDplus]

Category

Amines, Aromatic

Description

White to off-white solid; [MSDSonline]

Sources/Uses

Not commercially available; [HSDB]

Comments

Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] See "p-Phenylenediamine."

Biomedical References

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic