p-Anisidine

Synonyms

1-Amino-4-methoxybenzene; 4-Aminoanisole; 4-Anisidine; 4-Methoxy-1-aminobenzene; 4-Methoxyaniline; 4-Methoxybenzenamine; 4-Methoxybenzeneamine; Aniline, 4-methoxy-; Aniline, p-methoxy-; Anisole, p-amino-; Benzenamine, 4-methoxy-; p-Aminoanisole; p-Anisylamine; p-Dianisidine; p-Methoxyaniline; p-Methoxyphenylamine; [ChemIDplus] UN2431

Category

Amines, Aromatic

Description

Yellow to brown, crystalline solid with an amine-like odor; [NIOSH]

Sources/Uses

Both ortho and para isomers are used to produce azo dyes, while only the ortho form is used to produce synthetic guaiacol; [ACGIH]

Comments

Bladder cancer in animals observed in chronic feeding studies; Methemoglobinemia has been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] IARC classifies p-Anisidine as 3 (Not classifiable as to carcinogenicity to humans) and o-Anisidine as 2B (possibly carcinogenic to humans). A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; [ICSC]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

0.5 mg/m3

0.5 mg/m3

50 mg/m3

Excerpts from Documentation for IDLHs

Other animal data: Mice have survived exposures to concentrations of 10 to 30 mg/m3 for 2 hours/day, 6 days/week for 1 month with a only decrease in the excitability of nerves noted [Zaeva and Fedorova 1962]. Human data: None relevant for use in determining the revised IDLH.

0.03 mm Hg

Explanatory Notes

Flash point = 5 deg C; [HSDB] VP from HSDB;

MetHgb is secondary toxic effect

Not classifiable

Not Classifiable

Other Information

No other related information on this agent was found.