1-Chloro-4-(trifluoromethyl)benzene

Synonyms

p-Chlorobenzotrifluoride; (p-Chlorophenyl)trifluoromethane; 1-(Trifluoromethyl)-4-chlorobenzene; 4-Chloro-alpha,alpha,alpha-trifluorotoluene; 4-Chlorobenzotrifluoride; Benzene, 1-chloro-4-(trifluoromethyl)-; Toluene, p-chloro-alpha,alpha,alpha-trifluoro-; alpha,alpha,alpha-Trifluoro-4-chlorotoluene; p-(Trifluoromethyl)chlorobenzene; p-Chloro-alpha,alpha,alpha-trifluorotoluene; p-Chlorotrifluoromethylbenzene; p-Trifluoromethylphenyl chloride; para-Chloro-alpha,alpha,alpha-trifluorotoluene; para-Chlorobenzotrifluoride; para-Chlorotrifluoromethylbenzene; [ChemIDplus] UN2234

Category

Halogenated Monoaromatics

Description

Liquid with a strong but not unpleasant odor; [Merck Index] Clear colorless liquid; [CAMEO]

Sources/Uses

Used as an intermediate for dyes and pesticides; Also used as a environmentally friendly solvent and dielectric fluid; [Merck Index] Used as a solvent for paints, toners, and coatings, especially in the automotive industry; Used by workers and consumers in cleaners, degreasers, stain removers, and sealants; [IARC monographs, volume 125]

Comments

A skin, eye, mucous membrane, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [CAMEO] A skin and eye irritant; In a two generation reproductive feeding study with rats, the NOAEL in F1 and F2 offspring was greater than or equal to the highest dose tested (45 mg/kg bw); No evidence of mutagenicity; [IUCLID] Effects observed from single oral dose in rats include ataxia, tremors, and decreased limb tone; Effects observed in F1 female rats in oral reproductive study include increase in SGPT, decrease in erythrocyte counts, and lesions in the lungs; Decrease in erythrocytes, hemoglobin, and mean corpuscular and packed cell volumes observed in male rats in 90 day oral study; Increased liver weights observed in both sexes; No evidence of mutagenicity; [EPA] Effects observed in feeding studies at 400 mg/kg include liver hypertrophy in rats and mice and adrenal changes in rats; Doses of 50 mg/kg caused nephropathy in male rats; [NTP]

Biomedical References

7.63 mm Hg

LC50 (rat) = 22,000 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chlorobenzotrifluorides." VP from ChemIDplus;

high ambient temp required

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)